"Case 3
A 63-year-old Caucasian female presented with increasing lower urinary tract symptoms and hematuria. CT imaging revealed a 7.5 cm right lateral bladder mass with extension to the right pelvic sidewall and right-sided hydronephrosis requiring percutaneous nephrostomy. There was no evidence of metastatic disease, consistent with clinical T4 tumor. Transurethral Resection of Bladder Tumor (TURBT) demonstrated a large necrotic mass with pathology confirming urothelial carcinoma with 85% squamous and 2% sarcomatoid histology. She was treated with Accelerated Methotrexate, Vinblastine, Doxorubicin, and Cisplatin (AMVAC) for 6 cycles over the course of 4 months along with concurrent FBZ 1 gram three times weekly.
Follow-up CT revealed no evidence of disease with minimal residual thickening in the right inferior bladder wall. She declined to proceed with cystectomy and remains on surveillance with no evidence of progression."
Case Report in Clinical Oncology HERE.
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